ISSN: 2582-788X (Online)
Synthesis and antibacterial activities of 3H-benzooxazole-2, 2-dithiol and 3H-benzothiazole-2, 2-dithiol
Benzo-heterocycles are very well known compounds that bind strongly and selectively to so many metal ions. They readily form chelates with all transition metal ions through its two donor sulphur atoms. In this study, two derivatives of benzo-heterocyclic compound (3H-Benzooxazole-2,2-dithiol and 3H-Benzothiazole-2,2-dithiol) which was synthesized by refluxing one mole of 2-amino-phenol with one mole of CS2 in acetone, then one mole of 2-Amino-benzenethiol and one mole of CS2 in acetone for two hours respectively, as indicated in our earlier report. These compounds were studied to determine their effectiveness in the treatment of diseases caused by the tested organisms. The antibacterial activities of these ligands were carried out using the disc diffusion method. Antibacterial activities were exhibited by 3H-Benzooxazole-2, 2-dithiol and 3H-Benzothiazole-2, 2-dithiol, against Bacillus subtilis, Bacillus cereus, Pseudomonas aureginosa, Proteus mirabilis, and Salmonella typhi. The minimum inhibitory concentration was 10mg/ml for both Ligands with a zone of inhibition range of 10.6mm-10.8mm for 3H-Benzooxazole-2, 2-dithiol and with the zone of inhibition range of 10.8mm-11.1mm for 3H-Benzothiazole-2, 2-dithiol. The ligands can compete favourably with gentamycin which served as the reference drug.