Physiological changes in a patient undergoing bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation

Stem cell transplantation has been used for treating numerous diseases since the time its potentiality was identified. Doctors employ this technique to treat many types of blood cancers that damage or destroy the bone marrow. It is also used to restore bone marrow that has been damaged during cancer treatments such as radiation or chemotherapy. A stem cell transplant puts healthy blood stem cells back into the patient’s body so that they can produce healthy blood cells and get the immune system working again. When the healthy stem cells come from a donor, it’s called an allogeneic hematopoietic transplant. But such treatments have a high risk of infections associated. After the transplantation, patients are prone to various physiological changes for at least a few weeks before their bodies re-start producing blood cells on their own. It is always better to be aware of the various infections that a patient may suffer and the physiological changes faced by them before and post the transplantation. This article gives an insight into the various complications concerning patients with allogeneic hematopoietic stem cell transplantation with a detailed view of the causes of the reasons to go for such transplant and survival post such infection. Biomarkers have been found highly beneficial in the timely prediction of the onset of such allogeneic transplantation-induced diseases.