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International Journal of Applied Chemical and Biological Sciences

ISSN: 2582-788X (Online)

International Journal of Applied Chemical and Biological Sciences
Home Archive Volume 2 - Issue 4 Development of mouth dissolving tablet containing microencapsulated drug for taste masking by green synthesis

Volume 2   Issue 4

Research Article

Development of mouth dissolving tablet containing microencapsulated drug for taste masking by green synthesis

Abstract

The purpose of this study was to prepare formulation by masking the intensely bitter drug. Patient noncompliance i.e. pediatric, geriatric population are most sensitive to bad taste of medicament due to feeling bitted which may not necessary be wise, one of the key causes failure of oral dosage regimen (swallowing) Its reasoned taste masking carried out using technology depending on the type drug & dosage form but stability is major challenging task. Thus, the common method used to mask the unpleasant sensation is microencapsulation. This technology provides physical barrier between drug molecule & taste buds. Polymer can be used coating material, alone or in combination to produce a larger coat, depending on the drug bitterness. Eudragit e100 is a pH sensitive (<5) & have been popularly used for coating bitter medicament to achieve taste masking with perfection. Solubility of polymer in solvent (like organic solvent) & rate of solvent removal get cost range is very high. So that reduces this problem use green synthesis method, which are inexpensive, safe, eco-friendly & increase patient compliance & regulatory compliance. Development of mouth dissolving tablets contain microencapsulated drug are easy to swallow, no grittiness & with good mouth feel, cost effective, easy taken, major ideally for pediatric & geriatric patient & Bioavailability enhanced by taste masking technology compatible with MDTb formulation.

Keywords: Olopatadine hydrochloride Eudragit 100 Taste masking Microencapsulation Mouth dissolving tablets (MDTb)
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