ISSN: 2582-788X (Online)
DETERMINATION OF ANTI-DIABETIC AND ANTI-OXIDANT ACTIVITY OF Glycyrrhiza glabra ROOT EXTRACTS AND ITS PHYTOCHEMICAL SCREENING
Glycyrrhiza glabra is used as Ayurveda medicine for many decades due to its great and broad medicinal activity. The present study aimed at carrying out phytochemical analysis and evaluates its in vitro antidiabetic, and antioxidant activities of traditional medicinal plant Glycyrrhiza glabra which was collected from the nearby area of Mumbai, Maharashtra, India. An in vitro antidiabetic activity was evaluated by alpha-amylase methods and in vitro antioxidant activity by DPPH (2, 2-diphenyl-1- picrylhydrazyl) assay. The Aqueous extracts of Glycyrrhiza glabra root showed significant inhibition of alpha-amylase as compared to methanolic extract at various concentrations, whereas methanolic extract showed significant scavenging activity as compared to Aqueous extract at various concentrations. The phytochemical analysis revealed that Glycyrrhiza glabra root showed presence of secondary metabolites flavonoids, Saponin, glycosides, terpenoids etc. in different extracts which might be responsible for significant in vitro antidiabetic and antioxidant activities. Identification and isolation of active substances and secondary metabolites from such medicinal plants and their in vivo efficacy evaluation will help in further validation of pharmacological activities.